Why do I need a pyrogen filter?
A pyrogen filter is a specialised filter used in water treatment to remove pyrogens (fever-inducing substances, primarily lipopolysaccharides (LPS) from the cell walls of Gram-negative bacteria) from water. These filters play a particularly important role in the pharmaceutical industry, medical technology and dialysis technology.
Function of a pyrogen filter
A pyrogen filter typically uses ultrafiltration or special adsorption materials to remove pyrogens from the water. Key characteristics:
- Pore size: less than 0.005 µm (ultrafiltration range) to retain even dissolved pyrogens.
- Materials: often made of hydrophilic polyethersulphone (PES) membranes or other membrane materials with a high retention rate for endotoxins.
- Adsorption: some filters also contain materials that bind endotoxins through electrostatic or hydrophobic interactions.
Typical areas of application / industries
1. Pharmaceutical industry
- Production of injection solutions (WFI – Water for Injection)
- Cleaning steps in sterile production
- Part of ultrapure water systems
2. Medical applications
- Dialysis water: Pyrogens must be removed as they can trigger systemic reactions in di-alysis patients.
- Parenteral nutrition: Prevention of fever reactions in patients
- Eye rinses or wound rinses
3. Laboratories and research
- Production of pyrogen-free water for sensitive cell cultures or molecular biology (e.g. PCR)
- Use in animal testing to avoid undesirable immune reactions
4. Biotechnology and food industry
- In sensitive production processes where microbiological purity is crucial
Filter products
The pyrogen filtration system for producing pyrogen-free water using the mixed-bed process offers an impressive combination of a 5 µm pre-filter and a high-precision 0.05 µm filter for the reliable removal of pyrogens – ideal for pharmaceutical, medical and analytical applications. The design, which can be installed directly at the outlet of the mixed-bed system and is resistant to deionised water, ensures long-lasting, safe operation and, thanks to efficient pre-filtration, provides reliable protection against premature wear. Buy the filter system online now and benefit from maximum process reliability – including clear maintenance recommendations for consistently high water quality. The pyrogen filter system is supplied with all necessary installation materials, such as pressure hoses and fittings for the booster pump. The filter system is designed to produce pyrogen-free water. To protect the pyrogen filter, a sediment filter (filter rating: 5 micrometres) is fitted upstream of it. The pyrogen filter has a filter rating of 0.05 micrometres. The system is installed directly at the outlet of the mixed-bed system and, thanks to its components that are resistant to deionised water, is ideally suited for long-term use. Pre-filter (sediment filter) The sediment filter acts as a pre-filtration stage and protects the downstream pyrogen filter from resin abrasion from the mixed-bed cartridge, thereby preventing premature wear. Pressure booster pump: The pressure booster pump included in the package is connected upstream of the mixing bed to compensate for pressure loss caused by the mixing bed and the filtration elements for the downstream components, and to ensure an optimal supply of deionised water to the connected equipment. Pyrogen filter The pyrogen filter in its stainless steel housing provides a fine filtration stage and is designed to remove pyrogens (e.g. endotoxins), which are of particular critical importance in pharmaceutical, medical and analytical applications. Maintenance recommendation The filters should be inspected after three months and replaced after six months at the latest to ensure a safe process. For continuous operation, it is recommended to keep one sediment filter element (item number: 882088) and one pyrogen filter element (item number: 896493) in stock at all times. Note: Should failures occur in the connected downstream equipment during operation, the filter elements must be checked immediately and replaced if necessary. Deposits on the filter surface can lead to blockage of the filter elements.
Pressure booster station suitable for the Neomeris pyrogen filtration line. Buy this high-performance pressure booster station online now and benefit from constant water pressure – thanks to self-priming technology (up to 8 m), intelligent constant pressure control and the ‘Auto Setpoint’ function. The energy-efficient, whisper-quiet permanent magnet motor (just 47 dB(A), max. 550 W) ensures reliable pressure boosting with minimal power consumption and is ideal for supplying multiple taps simultaneously. Benefit from simple installation, integrated dry-run protection and robust construction (IPX4D) – the perfect solution for a convenient and long-lasting water supply. The pressure booster station is a compact, self-priming domestic water supply system with a maximum suction head of 8 m. Equipped with an exceptionally quiet, water-cooled permanent magnet motor and a convenient constant-pressure control system, it ensures consistent water pressure at all taps – regardless of fluctuations in inlet pressure or varying water consumption. Thanks to the ‘Auto Setpoint’ function, the system automatically adjusts the optimum constant pressure to suit the specific installation. Thanks to modern, energy-efficient motor technology, the pressure booster station requires only about half the electrical power (max. 550 W) compared to conventional domestic waterworks with the same flow rate. The fanless, water-cooled motor also ensures extremely quiet operation at just 47 dB(A). With protection class IPX4D, the unit is also suitable for frost-free outdoor installation. Features and benefits: Constant water pressure regardless of the flow rate Integrated frequency converter for stepless speed control Self-priming up to 8 m Very quiet operation at just 47 dB(A) Dry-run protection with automatic restart Thermal protection against overheating Compact design with all components in a single unit Quick and easy installation Typical applications: Domestic water supply Pressure boosting in private water systems Pumping water from cisterns, tanks or shallow wells Simultaneous supply to multiple taps The pressure booster station is a reliable, quiet and energy-efficient domestic water supply system. With intelligent control, constant pressure and a space-saving design, it offers a high level of convenience and a stable water supply for everyday use.
Pyrogen filter A pyrogen filter is a special type of filter used in water treatment to remove pyrogens from the water. Pyrogens are substances that can cause an immunological reaction in the body, in particular an increase in body temperature. These are usually endotoxins released by bacteria such as Escherichia coli (E. coli). The pyrogen filter consists of a filter element with a very fine pore size and an associated filter housing. The pyrogen filter is available with filter elements of 0.05, 0.1 or 0.2 micrometres, which you can select as required. This enables the filter to effectively retain particles and microorganisms, including pyrogenic bacteria that may be present in the water. In the modular water treatment plant, the pyrogen filter is used after other pre-treatment stages such as filtration and disinfection. After the water has been purified of particles and microorganisms, it is passed through a pyrogen filter to remove any pyrogens. Pyrogen filters are particularly important in industries where pyrogen-free water is crucial, such as in outpatient care, to ensure the optimal quality of surgical instruments. Overall, pyrogen filters play an important role in water treatment to ensure the quality and purity of the water and minimise potential exposure to pyrogenic substances.
The GR25 membrane filter element with an absolute filtration rating of 0.2 µm is designed for applications requiring the highest purity and process safety. It reliably removes the finest particles and microbiological contaminants from liquids with 99.98% retention. The filter element has a standard length of 9 ¾ inches and is compatible with common filter housings, allowing easy integration into existing systems.
The ring spanner is used to open the housing of the pyrogen filter line so that the filter element can be replaced. The ring spanner is used for safely opening and closing the housing. It enables easy and reliable handling during maintenance, especially when changing filters. Its precise shape ensures optimal torque transfer and prevents damage to the housing. Using the ring spanner ensures a quick and efficient filter change, contributing to the maintenance of the system’s flawless operation.
The sediment filter element for the Neomeris pyrogen filter system is a high-performance pre-filter that reliably removes coarse contaminants such as sand, rust, dust, and resin abrasion. This significantly increases the efficiency and service life of downstream filter systems. As an essential first stage of filtration, it protects the pyrogen filter from wear, ensures consistently high water quality, and is particularly suitable for applications where clean, treated water is crucial. Buy online now and benefit from easy installation, high compatibility (with item no. 882087), and straightforward, regular replacement for consistently optimal filtration. The sediment filter element is a key component of the Neomeris pyrogen filtration system and acts as the first stage of protection in the multi-stage filtration process. It is designed to reliably remove coarse contaminants in order to improve the service life and efficiency of the subsequent filtration stage. What is the sediment filter element used for? Function and performance The sediment filter acts as a pre-filter and protects the downstream pyrogen filter from resin abrasion from the mixed-bed cartridge and from premature wear. With its coarse micron rating, the sediment filter element reliably retains sand, dust, rust particles, resin abrasion, and similar contaminants. This first filtration stage is crucial as it prevents larger dirt particles from damaging or impairing the finer filter elements in the subsequent stages. Product benefits: Reliable sediment pre-filter for the Neomeris pyrogen filtration system Efficient first filtration stage: Removes coarse particles such as sand, dust, rust, resin abrasion from the mixed-bed cartridge, etc. Regular replacement required: Ensures consistent water quality and protects the system Easy integration: Can be easily integrated into the Neomeris pyrogen filter system Maintenance and replacement To ensure optimum performance and the best possible water quality, it is important to replace the sediment filter element regularly. The filters should be checked after three months and replaced after six months at the latest to ensure safe operation. Compatibility and installation The sediment filter element is suitable for replacement in the Neomeris pyrogen filter line (item number: 882087). Changing the filter is simple and can be carried out without specialist knowledge, thereby reducing maintenance requirements and improving user-friendliness.